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Old 10-02-2011
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Genetics Why Polycystic Kidney Disease Differs in Inheritance!

Polycystic kidney disease is a significant cause of renal failure that presents from early infancy to adulthood. Early-onset cases tend to affect one family member or siblings, while adult-onset cases often show a vertical pattern in the pedigree. Which of the following offers the best explanation of these facts?

A. Pleiotropy
B. Allelic heterogeneity
C. Locus heterogeneity
D. Multifactorial inheritance
E. Variable expressivity
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Old 10-02-2011
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Cool

I think its
C).Locus heterogeneity
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Old 10-02-2011
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allelic heterogeneity
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Default C

C locus heterogenecity
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im not sure maybe c
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C. Locus heterogeneity
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Default B

B, Allelic heterogenity
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Old 10-02-2011
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The answer is: C
Polycystic kidney disease occurs in two distinctive genetic forms—adult-onset and infantile. Infantile disease is autosomal recessive, while adult-onset disease is autosomal dominant. Confusion between these types can occur due to variable expressivity in the adult, dominant form. Occasional onset in young children may occur in adult-type disease. Consistency of early onset, the presence of consanguinity, and the lack of vertical transmission distinguish the infantile, recessive form. Polycystic kidney disease is an example of genetic heterogeneity, in which different mutations may cause similar phenotypes. This may be further divided into allelic and nonallelic (locus) heterogeneity. Allelic heterogeneity implies that there are different mutations at the same locus that both result in similar disease [i.e., the many fibrillin mutations in Marfan's syndrome]. In locus heterogeneity, mutations occur at different loci, yet the phenotype is similar. Locus heterogeneity also explains why certain disorders, such as polycystic kidney disease, Charcot-Marie-Tooth disease, sensorineural hearing loss, and retinitis pigmentosa may be inherited in several different fashions. A general rule predicts that the autosomal recessive forms of these diseases will be more severe, the autosomal dominant forms less so. It is especially important to recognize the possibility of genetic heterogeneity when counseling patients in regard to recurrence risks.
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