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Old 10-03-2011
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Question Pathology questİon

A 5-year-old male with no previous medical history is brought to the ER by his mother because he accidentally ingested a large dose of rat poison. He is conscious but appears quite agitated. On physical exam, he is found to have a blood pressure of 110/70 and a heart rate of 90. Labs are significant for an elevated PT but a normal PTT. The patient should be immediately treated with
A. atropine
B. flumazenil
C. N-acetylcysteine
D. protamine
E. vitamin K
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Old 10-03-2011
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E.Vitamine K
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Old 10-03-2011
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E. vitamin K
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Old 10-03-2011
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Quote:
Originally Posted by aknz View Post
E. vitamin K
Any explanation would be appreciated.
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Old 10-03-2011
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vit K for its immediate anticoagulation properties?!!
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Old 10-03-2011
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correct answer is E. As you might have guessed from his elevated PT level, the active ingredient in rat poison is warfarin. It acts as an anticoagulant by interfering with the normal hepatic synthesis of the vitamin K-dependent clotting factors II, VII, IX, and X. The most important adverse effect of warfarin is bleeding. The action of warfarin can be reversed with vitamin K.
Atropine (choice A) is used as an antidote for anticholinesterase toxicity (e.g., ingestion of organophosphates).
Flumazenil (choice B) is used as an antidote for benzodiazepine toxicity (e.g., Valium).
N-acetylcysteine (choice C) is used as an antidote for acetaminophen toxicity.
Protamine (choice D) is used as an antidote for heparin overdose. Note that heparin enhances the activity of antithrombin III, producing its anticoagulant effect. Heparin toxicity would have resulted in an elevated PTT.
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Old 10-04-2011
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E. vitamin K decrease pt
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