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Old 10-03-2011
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Default Renin status with an ARB

I am having some trouble grasping this concept and hopefully one you guys can shed some light. So here is the question. Assuming you place a patient on an ARB (Losartan) what happens to the plasma renin activity?

With an ACE inhibitor we know that renin will increase due to the loss of negative feedback provided to the JGA by angiotensin 2. So by this logic since an ARB does not inhibit AT 2 from forming would this not bring the negative feedback of AT2 into play and thus decreasing Renin secretion?

Also whats going to happen to aldosterone?
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Old 10-03-2011
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Originally Posted by moe2185 View Post
I am having some trouble grasping this concept and hopefully one you guys can shed some light. So here is the question. Assuming you place a patient on an ARB (Losartan) what happens to the plasma renin activity?

With an ACE inhibitor we know that renin will increase due to the loss of negative feedback provided to the JGA by angiotensin 2. So by this logic since an ARB does not inhibit AT 2 from forming would this not bring the negative feedback of AT2 into play and thus decreasing Renin secretion?

Also whats going to happen to aldosterone?
ARB exert their effects by antagonizing ATII receptors in the glomerulosa of the suprarenal glands so aldosterone is not produced. ATII exerts negative feed back on renin by acting on the angotensin receptors in the kidneys. however since the person can't produce aldosterone the feedback effect of aldosterone on ATII is lost so more ATII is produced. however the ATII can't act on itrs receptors to feedback negatively on renin secretion so even renin secretion is high. if renin is high then ATI will be high.
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Old 10-03-2011
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Originally Posted by nativedoc2 View Post
ARB exert their effects by antagonizing ATII receptors in the glomerulosa of the suprarenal glands so aldosterone is not produced. ATII exerts negative feed back on renin by acting on the angotensin receptors in the kidneys. however since the person can't produce aldosterone the feedback effect of aldosterone on ATII is lost so more ATII is produced. however the ATII can't act on itrs receptors to feedback negatively on renin secretion so even renin secretion is high. if renin is high then ATI will be high.
in other words ARB will cause high ATI, ATII, renin and low aldosterone. but no effect on bradykinin (uworld)
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