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Old 10-06-2011
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Question antagonizaation of vascular and cardiac actions of norepinephrine

Which of the following drugs antagonizes both the vascular and cardiac actions of norepinephrine?
A. Atenolol
B. Esmolol
C. Labetalol
D. Metaproterenol
E. Prazosin


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Old 10-06-2011
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after eliminating other options i ll go with labetalol
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Old 10-06-2011
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that would be nonselective beta-blocker so yes is it labetalol?

atenolol and esmolol = Beta2 antagonists

metaproproterenol = beta2 agonist

prazosin = alpha1 antagonist

though labetalol has some beta2 agonist activity but its very minor and at high doses atenolol and esmolol have b2 antagonist activity.

but the most likely answer is labetalol ?
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Old 10-07-2011
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answer is labetalol
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