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Old 10-13-2011
INCOGNITO's Avatar
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Drug Calculating the drug plasma level

A drug achieves a plasma level of 16mg/L shortly after administration of first oral dose. If half life and dosing intervals are both 6hrs what is approx plasma level before administration of 5th oral dose?

a) 30mg/L
b) 15mg/L
c) 31mg/L
d) 24mg/L
e) 28mg/L
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b) 15 mg/l
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c)31mg/L

1st hr 8(t1/2 of 16) + 16(dose) = 24

2nd hr 12(t1/2 of 24) + 16(dose) = 28

3rd hr 14(t1/2 of 28) + 16(dose) = 30

4th hr 15(t1/2 of 30) + 16(dose) = 31 --> Before 5th dose.

5th...
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Old 10-14-2011
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Correct Answer correct answer

correct answer is 15mg/L
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Quote:
Originally Posted by INCOGNITO View Post
correct answer is 15mg/L
I think I read the question wrong way. Anyway can you please explain it for me??
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question says JUST BEFORE 5th dose is given so bottom WHERE ARROW IS GIVEN its 15 mg/L

pardon for low quality pic..

Calculating the drug plasma level-dose.png
click image to enlarge
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