Esophogeal cancer, why most commonly in the middle part? - USMLE Forums
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Old 10-15-2011
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GIT Esophogeal cancer, why most commonly in the middle part?

Why the majority esophageal cancer occurs in middle part of esophagus (50%)? I though the lowest part is the transformation zone from pseudostratified squamous to columnar cell.
This lower zone should be more prone to adenocarcinoma formation.

Am I wrong?
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Old 10-15-2011
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Squamous cell carcinoma is most commonly found in the middle part.

But Adenocarcinoma is most commonly found in the lower third.
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Old 10-15-2011
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Quite the opposite, SCC is more prevelent in third world coutries due to heavy smoking problems. According to Goljan's pathology, adenocarcinoma of esophagus (due to esophogeal reflux) is more common than SCC in the US. . If esophageal cancer in the middle part of esophagus is SCC like you said, how come the cancer in middle part of esophagus accounts for > 50% of all esophaeal cancers in the US?
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This thread might help
Most common esophageal cancer

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