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Old 03-16-2015
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Question Serum sickness vs Anaphylaxis

How to differentiate between drug induced serum sickness from drug induced anaphylaxis based on presentation?
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Old 03-17-2015
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anaphylaxis usually occurs immediately or withing an hour, also it would be life threatening with possible laryngospasm (stridor) and signs of shock.

where as serum sickness on the other side takes a couple of days to even weeks to occur after injection of the substance. which would present with a rash, fever, splenomgaly and painful lymphadenopathy
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Old 03-17-2015
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spacemaster lay out a big a points there.

Drug reactions can be systemic or organ specific. Systemic reactions are anaphylaxis, vasculitis, serum sickness, and drug fever. Organ-specific reactions commonly affect the skin but can be hematologic, pulmonary, hepatic, or renal.
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