What type of Hypersensitivity is Chronic Autoimmune Gastritis? - USMLE Forums
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Old 03-17-2015
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Default What type of Hypersensitivity is Chronic Autoimmune Gastritis?

Autoimmune gastritis (type A chronic) is related to auto-antibodies to parietal cells, but in pathoma it says the pathogenesis is mediated by t-cells (referring to it as Type 4 HSR),
In FA immuno section pernicious anemia is a type 2 HSR

Is first aid just referring to pernicious anemia alone is a type 2, but chronic gastritis is a type 4 HSR that leads to pernicious anemia (type 2)?
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Old 03-17-2015
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Quote:
Originally Posted by OxanaSmily View Post
Autoimmune gastritis (type A chronic) is related to auto-antibodies to parietal cells, but in pathoma it says the pathogenesis is mediated by t-cells (referring to it as Type 4 HSR),
In FA immuno section pernicious anemia is a type 2 HSR

Is first aid just referring to pernicious anemia alone is a type 2, but chronic gastritis is a type 4 HSR that leads to pernicious anemia (type 2)?
Keep it simple. Its actually a mixed hypersensitivity. For the boards, consider it as Type 2, where antibodies are made against the Parietal cells, and they get destroyed.

Later in the course of the disease, Cell-mediated takes over. This is true for many diseases that start as Type 2, and end up as Type4 (Like Hashimoto, but that is mostly Type4). You look at the INCITING event that leads to hypersensitivity. Who came first? The Antibodies or the T-Cells? And thats the convention. Otherwise, most diseases aren't solely antibody or cell-mediated. There is a mixture.

Bottom line, decide on the intitating event. For Pernicious anemia, the initiating, and the first response is Type 2. Hence, select type 2 for the boards.

Hope that helps!
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Old 03-17-2015
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Thanks you!
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Old 07-09-2016
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thank you...
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