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Old 03-20-2015
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Blood What kind of drug hypersensitivity GOLJAN

So, If we say that a 17 yo female is being treated for rheumatic fever and develops a generalized rash and wheezing after a penicillin injection what kind of hypersensitivity is this?

the same case scenario but the patient develops hematuria after the penicillin injection


another patient who took quinidine and also developed hematuria


What kind of hypersensitivity is each?
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Old 03-22-2015
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Goljan Since now one answered!

Quote:
Originally Posted by spasemaster View Post
So, If we say that a 17 yo female is being treated for rheumatic fever and develops a generalized rash and wheezing after a penicillin injection what kind of hypersensitivity is this?

the same case scenario but the patient develops hematuria after the penicillin injection


another patient who took quinidine and also developed hematuria


What kind of hypersensitivity is each?
I'm gonna answer this since no one answered

First one is a hypersensitivity type 1 due to the immediate release of histamine leading to wheezes and a rash

second one is due to type 2 hypersensitivity as Antibodies adhere to RBCs cause their INTRAVASCULAR hemolysis which leads to hematuria.

third is type 3 hypersensitivity as quinidine forms immunocomplexes on RBCs that are later destroyed.
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