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Old 03-20-2015
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Default Zn deficiency

Why does Zn deficiency predispose a person to alcoholic cirrhosis?
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Old 03-20-2015
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Actually I think Alcohol causes zinc deficiency which will co-act in causing cirrhosis along with alcohol.

Giving cirrhotic patients zinc might improve some of their symptoms:
Zinc deficiency
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Old 03-20-2015
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Originally Posted by spasemaster View Post
Actually I think Alcohol causes zinc deficiency which will co-act in causing cirrhosis along with alcohol.

Giving cirrhotic patients zinc might improve some of their symptoms:
Zinc deficiency
But FA says under the zinc deficiency: May predispose to alcoholic cirrhosis

So doesn't this mean the deficiency leads TO cirrhosis and not the other way around?
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ok so from what I gathered. Zn def occurs because of alcoholic liver cirrhosis because alcohol decreases zn absorption and increases urinary zn excretion, therefore you end up with the deficiency, let me know if you think otherwise.
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Alcoholic liver disease is associated with zinc decrease in the liver. Therefore, we examined whether dietary zinc supplementation could provide protection from alcoholic liver injury. Metallothionein-knockout and wild-type 129/Sv mice were pair-fed an ethanol-containing liquid diet for 12 weeks, and the effects of zinc supplementation on ethanol-induced liver injury were analyzed. Zinc supplementation attenuated ethanol-induced hepatic zinc depletion and liver injury as measured by histopathological and ultrastructural changes, serum alanine transferase activity, and hepatic tumor necrosis factor-α in both metallothionein-knockout and wild-type mice, indicating a metallothionein-independent zinc protection. Zinc supplementation inhibited accumulation of reactive oxygen species, as indicated by dihydroethidium fluorescence, and the consequent oxidative damage, as assessed by immunohistochemical detection of 4-hydroxynonenal and nitrotyrosine and quantitative analysis of malondialdehyde and protein carbonyl in the liver. Zinc supplementation suppressed ethanol-elevated cytochrome P450 2E1 activity but increased the activity of alcohol dehydrogenase in the liver, without affecting the rate of blood ethanol elimination. Zinc supplementation also prevented ethanol-induced decreases in glutathione concentration and glutathione peroxidase activity and increased glutathione reductase activity in the liver.


In conclusion, zinc supplementation prevents alcoholic liver injury in an metallothionein-independent manner by inhibiting the generation of reactive oxygen species (P450 2E1) and enhancing the activity of antioxidant pathways.

hope this helps
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yagoy (03-20-2015)



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