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Old 03-23-2015
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Default Oxy Hb dissociation curve: sickle cell disease

According to U world, the oxy Hb dissociation curve of Hb S is shifted to the right..Can anyone please explain why it is so?

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Old 03-23-2015
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Is it because Hb S has low affinity for oxygen???
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Quote:
Originally Posted by samusmle33 View Post
Is it because Hb S has low affinity for oxygen???
Because of increased 2,3 DPG which is assosciated with anemias.
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Actually it's because during sickle cell crisis, HbS precipitates facilitating O2 unloading to tissues and you know that when Hb does that = low affinity = curve shifting to the right.
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