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Old 03-26-2015
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Default G6PD and Malaria

In FA, it is mentioned that under the treatment section of G6PD:

If life-threatening use IV quinidine or artesunate (test for G6PD deficiency)

For P.vivax/ovale, add primaquine for hypnozoite (test for G6PD deficiency)

I understand that G6PD protects against Malaria, what I do not understand is the context FA uses G6PD deficiency.
What are they telling me exactly? why is it important to test for G6PD deficiency? and how will a +ve or -ve result change my treatment?
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Old 03-26-2015
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If you treat any kind of malaria Falciparium/ovale/vivax using quininine or primaquine and the patient has G6PD DEF. you will eradicate the malaria but induce severe haemolisis from the drug due to the G6PD deficiency.So you must be sure your patient is not G6PD deficient.

G6PD protection against malaria also seen in sickle cell trait doesnot mean the patient cannot have malaria.It only provides some protection meaning they have it but less frequently.However when they do its more fatal because they already have a RBC defect.

This also explains the predominance of this enzyme deficiencies in Africa because of natural selection preserving individuals with this defects.

Lastly i hope you also understand the protection is against the Falciparium stain only.

Any more questions am open.Hope it helped.
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yagoy (03-27-2015)


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