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Old 03-26-2015
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Default O2 arteriovenous difference

Is it true that skeletal muscle arteriovenous difference (and therefore oxygen extraction) decrease with increased blood flow to the muscle while it stays constant in the kidneys with increased blood flow?
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Old 03-26-2015
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Hmmm, for the muscles yeah. As the flow increases, the muscles don't need to extract that much oxygen as they are receiving more O2/volume of blood delivered. Hence, the extraction or the AV difference comes down.

For kidneys, its almost constant. It appears that it doesn't change as the Renal circulation is overperfused in terms of nutrient requirements, so that venous P02 stays high most of the time. Hence, changes in flow don't generally seem to affect the extraction, unless the flow is very decreased in which case the extraction will increase.

Hope that helps!
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