X-linked (Bruton) agammaglobulinemia - USMLE Forums
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Old 03-31-2015
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Default X-linked (Bruton) agammaglobulinemia

why does the patient have absent/scanty lymph nodes and tonsils?
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Old 03-31-2015
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As I recall there's a defect in maturation of B lymphocytes in this disease.
Now, if you recall both T and B lymphocytes are made in the BM but each undergoes maturation in different organs. B cells mature in Lymph nodes. Since there's a defect there, lymph nodes will be either absent or atrophic. And as you know tonsils are nothing but lymph nodes.

Is this something specific to Bruton? NOPE, it can occur in other lymphocyte defective diseases. BUT it's seen commonly with Bruton.
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