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Old 10-22-2011
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Default 52 yr old with CA breast

A 52 year old woman dies 9 months after being diagnosed with well differentiated ductal CA of the right breast metastatic to the brain, lung, and liver. Her mother and one of her sisters also have died of breast cancer. Which of the following molecular abnormalities is most likely to be found in this pt?

A. amplification of the HER2 gene in somatic cells
B. amplification of the N-myc gene in the neoplastic cells
C. deletion of the Rb locus in healthy somatic cells
D. fusion of the BCR and C-ABL genes in neoplastic cells
E. germline inactivation of the BRCA1 gene
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Old 10-22-2011
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Originally Posted by doc Mm View Post
A 52 year old woman dies 9 months after being diagnosed with well differentiated ductal CA of the right breast metastatic to the brain, lung, and liver. Her mother and one of her sisters also have died of breast cancer. Which of the following molecular abnormalities is most likely to be found in this pt?

A. amplification of the HER2 gene in somatic cells
B. amplification of the N-myc gene in the neoplastic cells
C. deletion of the Rb locus in healthy somatic cells
D. fusion of the BCR and C-ABL genes in neoplastic cells
E. germline inactivation of the BRCA1 gene

Please be E???
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Old 10-22-2011
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Answer is A.
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