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  #1  
Old 10-27-2011
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Liver Liver transplant and HLA Matching

Why HLA matching is not done in Liver transplants?
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Old 04-14-2012
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Because
1 there is not enough time to go for testing cadaver donor to recipient HLA compatibility.
2 HLA compatibility does not seem to confer any beneficial reduction of rejection rates.
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Old 04-14-2012
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Quote:
Originally Posted by slumdog View Post
Because
1 there is not enough time to go for testing cadaver donor to recipient HLA compatibility.
2 HLA compatibility does not seem to confer any beneficial reduction of rejection rates.
Are you sure?
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Old 04-14-2012
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Quote:
Originally Posted by Valkoff View Post
Are you sure?
That´s the information I have based on a published article. If you have any updates, feel free to share here.
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Old 10-24-2013
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Well, the role of HLA in liver transplant is uncertain since there are no studies which show its beneficial effect on liver transplant survival. However, if you want to get the details about its use, you can consult with your doctors or opt for a free online consultation with the experts of kidney transplant clinics like Justsavelives.com etc. who can give you detailed information about it.
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Old 10-24-2013
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slumdog is right.

HLA matching is not applied to heart, lung and liver transplants for the following practical reasons:

- Patient pool is too small for matching.

- Cold ischaemia time is too short. Hearts must be transplanted within 6-7 hours compared with 24 hours for kidneys. Long distance organ sharing therefore is not feasible.

- Size constraints. Unlike kidneys small hearts (e.g pediatric) cannot be transplanted into large adults and vice versa.

- Most heart, lung and liver transplants are performed for reasons of clinical urgency. This overrides any matching considerations.

This does not mean HLA matching does not have an effect.
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