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Old 10-31-2011
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Skin Skin lesion that does not become malignant!

A 21-year-old, fair skinned, Caucasian female with a family history of skin cancer presents to your office for an evaluation of a mole on her arm. A biopsy is taken of the mole and sent to the pathologist. Which of the following on the differential diagnosis does not lead to a malignant skin cancer?

A. Xeroderma pigmentosum
B. Dysplastic nevus
C. Seborrheic keratosis
D. Albinism
E. Actinic keratosis
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Old 10-31-2011
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c??? its paraneoplastic syndrome kinda stuff.. due to an underlying malignancy so cant be malignant itself
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Old 10-31-2011
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D is the answer.
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Old 10-31-2011
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Surely C. Seborrhic keratosis, is a benign lesion and cannot lead to a malignancy!

while D. Albinism increases the risk to have SCC, BCC, and melanoma ....
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Old 10-31-2011
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Old 11-01-2011
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A 21-year-old, fair skinned, Caucasian female with a family history of skin cancer presents to your office for an evaluation of a mole on her arm. A biopsy is taken of the mole and sent to the pathologist. Which of the following on the differential diagnosis does not lead to a malignant skin cancer?

A. Xeroderma pigmentosum
B. Dysplastic nevus
C. Seborrheic keratosis
D. Albinism
E. Actinic keratosis
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Old 11-01-2011
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The correct answer is C.
Seborrheic keratosis is a noncancerous, benign skin growth that originates in keratinocytes and does not lead to a malignant skin cancer. However, the sudden appearance of diffuse seborrheic keratosis may be the sign of an underlying malignancy (Leser-Trelat sign). Note however, that the question is specifically asking about malignant skin cancer. Actinic keratosis can lead to squamous cell carcinoma of the skin. Xeroderma pigmentosum and albinism can lead to melanoma, basal cell carcinoma and squamous cell carcinoma. Dysplastic nevus can lead to malignant melanoma.
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