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Old 11-02-2011
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Default Quinidine for digoxin toxicity

FA 2011 page283 said quinidine can be used for digoxin toxicity.

It mentioned that 'quinidine decrease digoxin clearance and displace digoxin from tissue-binding site'.

I think it's paradoxical: since it displaces digoxin from tissue-binding sites, why it drcreases digoxin clearance?? what is the mechanism here?

Can anybody help? thx a lot!
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Old 11-02-2011
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it doesnt say quninidinde can be used for digoxinn toxicity.. it says it causes toxicity be displacing digoxin from its binding site...
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Old 11-02-2011
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Quinidine reduces renal and biliary clearance of digoxin by inhibiting efflux transporter P-glycoprotein therefore its plasma concentration is increased . hope it helps !
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The above post was thanked by:
drhma (11-02-2011), gokulramani (01-05-2016), ZoeZ (11-15-2011)
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Old 11-02-2011
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there fore Quinidine is contraindicated in Digoxin toxicity
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Old 01-04-2016
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BUMP - how does displacing it from tissue sites decrease it's clearance?
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