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  #1  
Old 11-04-2011
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Immunology Pink red skin blotches; which Immunoglobulin!

25-year-old female presents with pruritic, pink-red blotches along her extremities after starting a new antibacterial drug. Several of the lesions are pink-red rings with pale centers. In this disorder, which of the following is deposited in the superficial microvasculature of the skin and oral mucous membranes?

A. IgM
B. IgD
C. IgA
D. IgG
E. IgE
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Old 11-04-2011
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Ccccccccccccc
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Old 11-04-2011
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igG
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Old 11-05-2011
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E. IgE

maybe it is an anaphylaxis due to drug hypersesitivity....
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Quote:
Originally Posted by scopusmount View Post
25-year-old female presents with pruritic, pink-red blotches along her extremities after starting a new antibacterial drug. Several of the lesions are pink-red rings with pale centers. In this disorder, which of the following is deposited in the superficial microvasculature of the skin and oral mucous membranes?

A. IgM
B. IgD
C. IgA
D. IgG
E. IgE
İs it İgE? I guess so..
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Old 11-05-2011
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IgE?
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Old 11-05-2011
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Wink

I first select IgA, because this immunoglobulin is on mucus membrane and some drug-iduced erythema multiformes such as vancomycin.
However, Overally it should be IgM, so my second choice is IgM.

Any further explanation is appreciated.
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Quote:
Originally Posted by Evergreen View Post
I first select IgA, because this immunoglobulin is on mucus membrane and some drug-iduced erythema multiformes such as vancomycin.
However, Overally it should be IgM, so my second choice is IgM.

Any further explanation is appreciated.

why?????

it is clear, and there is a clue in the question (marked in red)



Quote:
Originally Posted by scopusmount View Post
25-year-old female presents with pruritic, pink-red blotches along her extremities after starting a new antibacterial drug. Several of the lesions are pink-red rings with pale centers. In this disorder, which of the following is deposited in the superficial microvasculature of the skin and oral mucous membranes?
this description is typical for anaphylactic reaction...

that the widespread vasodilation and increased vascular permeability that develops in anaphylaxis allow fluid to accumulate in the superficial dermis producing small weals with pale center encircled by a red flare...
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  #9  
Old 11-05-2011
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http://en.wikipedia.org/wiki/Erythema_multiforme
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Old 11-06-2011
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Quote:
Originally Posted by tariqkaseda View Post
why?????

it is clear, and there is a clue in the question (marked in red)





this description is typical for anaphylactic reaction...

that the widespread vasodilation and increased vascular permeability that develops in anaphylaxis allow fluid to accumulate in the superficial dermis producing small weals with pale center encircled by a red flare...

I think it's erythema multiforme. In Wikipedia (as inno mentioned), IgM is mostly present in the lesions.
scopusmount! Please tell us the correct answer!
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Old 11-07-2011
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Quote:
Originally Posted by inno View Post
read d wiki given well
it is erythema multiformae
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Old 11-07-2011
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So what is the answerR???
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Igm deposits is the answer
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Old 11-07-2011
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A. IgM as i think still thinking y not IgA ?????
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Old 11-08-2011
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Question

which type of hypersensitivity reaction is this
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