A 35-year-old male presents with frequent severe headaches, heart palpitations and severe sweating. He denies any drug use and his family history is significant for a paternal uncle dying for unknown reasons at the age of 33. On examination, he is noted to have an elevated blood pressure, cervical lymphadenopathy and several thyroid nodules. Several imaging studies are ordered, revealing a medullary carcinoma of the thyroid, pheochromocytoma and hyperparathyroidism. What is his most likely diagnosis?
- A. VIPoma
- B. Multiple Endocrine Neoplasia-II
- C. Multiple Endocrine Neoplasia-III
- D. Multiple Endocrine Neoplasia-I
- E. Kallman Syndrome
Which of the following genes is the origin of his diagnosis?
- A. Ras
- B. Erb-B2
- C. C-kit
- D. Ret
- E. Abl