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Old 04-28-2015
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Default Glutaminase induction in chronic acidosis

Why is glutaminase induced in chronic acidosis?
How does ammonium excretion help in chronic acidosis?
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Glutaminase is the enzyme which breaks down Glutamine into Glutamic acid + Ammonia(NH3)



This Free ammonia which is formed by the Glutaminase Enzyme will be able to trap one H+ to form NH4+ which is not an acid...so basically to correct acidosis it increases glutaminase production...

The whole thing occurs in the kidney where NH3 being a gas can move from cell to the lumen but once it traps the H+ and becomes NH4+ it will not be able to move back into the cell and will thus be eliminated in the urine

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Thanks a lot
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