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Old 04-29-2015
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RBC Thalassemia

Why is it that in Beta Thalassemia minor HbA2 is increased more than HbF and in Beta Thalassemia major the increase is more in HbF and lesser in HbA2?

Any idea?
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Old 04-30-2015
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So basically what you are asking is,

Why doesnt HbA2 replace HbA?

I mean that makes complete sense right HbA2 replacing whole of HbA since its defective but instead we get a rise in HbF which is only capable of delivering oxygen when O2 stats are high and it has high affinity for oxygen which is bad for the tissues and 2,3-BPG has no effect on HbF

This makes complete sense I dont know man I am surprised I never thought of this

Two or Three things are there I can think of:

1.HbF is high during the first 6months so being high its protective I guess and its high in everyone but its HIGH like you said

2.Since normally the HbA2 is only 2.5% while the majority of the rest is HbA when hematopoisis occurs in the medullary tissues so I think when in Beta thalassemia major extra medullary hematopoisis sets in the old fetal days are back so HbF is then synthesized

3.We treat this patients with HYDROXYUREA which causes are rise in levels of HbF, so levels are HIGH

I guess number 2 but I dont know man...very good point
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Last edited by CleverFOX; 04-30-2015 at 11:42 AM.
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