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Old 04-30-2015
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Default DNA polymerase III

Does DNA polymerase III have a repair function too? Kaplan says that DNA pol gamma and DNA pol III do not participate in 3 - 5 exonuclease activity. Plz clarify
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If by repair mechanism you mean Proof Reading then YES

This is what Lippincott's Biochemistry Book has to Say: [ed5,pg405]
DNA pol III has a "proof reading" activity (3'-5' exonuclease) activity which checks to make certain the added nucleotide is correctly matched to its complimentary base on the template.

[Ed5,pg407] states DNA Pol gamma has proof reading capability.

Hope this helps
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Quote:
Originally Posted by CleverFOX View Post
If by repair mechanism you mean Proof Reading then YES

This is what Lippincott's Biochemistry Book has to Say: [ed5,pg405]
DNA pol III has a "proof reading" activity (3'-5' exonuclease) activity which checks to make certain the added nucleotide is correctly matched to its complimentary base on the template.

[Ed5,pg407] states DNA Pol gamma has proof reading capability.

Hope this helps
Thank you
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Old 04-30-2015
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In eukaryotes

1) DNA polymerase beta do the DNA repairing work.
2) DNA polymerase delta builds the leading strand.
3) DNA polymerase gamma replicates mitochondrial DNA.
4) DNA polymerase alpha makes its own primase and then makes okasaki segment also by itself.
*THESE WERE THE POINTS WHICH ARE UNIQUE and DIFFER FROM PROKARYOTIC DNA REPLICATION.
* rest is same between prokaryotic and eukaryotic DNA replication.
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