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Old 11-10-2011
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Default Cox 1 and 2

can someone please explain the different functions of cox 1 and 2..its really confusing...effects in high and low doses and why selective cox 2 inhibitors increase the risk of cvs events...

this concept is so frequently tested in all the nbmes and the exams...
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Old 11-10-2011
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i found dis really useful....i hope dis helps ugood luck.
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heman466s (11-10-2011)
Old 11-10-2011
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thats really a good Q ,, the difference between COX 1 & COX 2 that COX 1 is constitutive meaning is produced all the time as it plays a great protective role live that in GIT ( for producing the protective PGs) ,,while COX2 is induced in inflammation case only check this photo ,, COX 2 inhibitor as coxib is COX 2 dependent PGI2 production and in case of therosclerosis COX 2 plays a role of producing more TxA than producing PGI2 so coxib by this way will inhibit PGI2 while more TxA is formed promoting more platelet aggregation > danger of coronary occlusion and myocardial infarction and that the main role that make it danger that it makes increased TXA amount in realation to protacyclin

also i read through searching the net that it causes an increase in free radicals which also has a big danger on CVS that due to that in vascular inflammation coxib will lead to inhibtion of antithrombotic protacyclin formation by arachidnate flux through cox 2 so there more arachidonic acid will go through pathway of leukotriens such as LTB4 that will produce more oxygen radicals through leuckocyte formation , also it was found that coxib causes mitocondrial uncoupling
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The above post was thanked by:
heman466s (11-10-2011), mayankkaushal (02-12-2013)


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