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Old 11-14-2011
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Drug Drug with highest incidence of toxicity!

Four drugs produce the same therapeutic effect by the same mechanism, but each has a unique toxicity. When used at a maximally effective therapeutic dose, the drug with which of the following sets of characteristics is most likely to have the highest incidence of toxicity?

Median effective dose , Toxic dose1/effective dose99
A 0.5x , 2.8
B 1x , 2.1
C 5x , 4
D 33x , 3

Please Explain your answer
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Old 11-14-2011
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option B
because it has lowest therapeutic index,,,it means it's median effective dose and median toxic dose are very close to each other,,,giving you very small therapeutic window. . .
am i right?
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Old 11-14-2011
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yes............ thank u 4 your respons...
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