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Old 05-17-2015
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Default molecular pathogen. of CRC

anyone know if is this correct:

APC pathway -> right sided colon caner
Microsatellite instability -> left sided colon cancer

i keep seeing different things and i am kind of confused. if anybody knows and can explain these plz let me know
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Old 05-18-2015
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Its the other way around. APC causes left sided lesions (apple core lesions) which present as pencil thin stools.
MSI causes right sided lesions and may present as iron deficiency anemia
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Old 05-18-2015
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I havent come across any text with specific pathways for specific sites. Where did you find that pathway?

As far as I know, CRC = Either it can be

With Familial Polyps
Assoc with APC (ch5q inactivation)
With sequential deletions in
APC > k-ras > p53/DCC (deleted in colon cancer)

or Without polyps - LYNCH Syndrome - DNA MISMATCH REPAIR
M - MSH-2(ch2) MLH-1 (ch3)

Note that there is a smiliar gene - DPC - Deleted in pancreatic cancer. Both these deletions are on CH 18!

Sites > Most common is RECTO SIGMOID
ASCENDING AND DESCENDING
and finally TRANSVERSE AND CECUM.

Hope this helps.
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Old 05-29-2015
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just saw these replies, thanks guys!!!
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