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  #1  
Old 11-25-2011
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Question 80 Year Old Hormone Level!

An 80 yr old healthy male has bp of 120/70 & heart rate of 72/min. He walks 4 miles daily. In comparison to a healthy 50 yr old male, which of his hormone level will be HIGHER?

a: testosterone
b: insulin
c: IGF1
d: thyroid
e: cortisol
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I want to say Cortisol since more stress on the old man than the 50 year old. Anyone else know for sure?
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Old 11-25-2011
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where is this question from?
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Old 11-25-2011
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I was doing a Kaplan question that asked what would be increased in some that is doing physical activity, and the answer was vascular endothelial growth factor. So going to assume that growth factors in general are increased during heavy physical activity. So IGF-1.
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Old 11-25-2011
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But the question is asking which hormon is higher compared to the 50 year old
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Old 11-25-2011
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i told thyrooo in other topic.
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Old 11-26-2011
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im not sure i would say IGF1...plz what's the right answer!
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Old 11-26-2011
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Its cortisol : p
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Old 11-26-2011
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hey!! whered u get that question from?
a friend of mine took the exam yest! n she had the exact same question n she didnt kno the answer!!
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Old 11-26-2011
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e: cortisol
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Old 11-26-2011
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Quote:
Originally Posted by legend View Post
An 80 yr old healthy male has bp of 120/70 & heart rate of 72/min. He walks 4 miles daily. In comparison to a healthy 50 yr old male, which of his hormone level will be HIGHER?

a: testosterone
b: insulin
c: IGF1
d: thyroid
e: cortisol
testosterone should techinicallly decrease.

Insulin and IGF-1 , go hand in hand, when one increases the other should as well.
older ppl - I am assuming tend to have more of hypo.
so that leaves me with CORTISOL.

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I think answer should be one of the stress hormones.Now the cortisol if increased in this person should have resulted in Htn overtime and thyroid should increase the HR but since both this thing are normal I will go with IGF-1 as it also helps in growth of cartilage and in old person the wear and tear is more so I think increase IGF-1 will help.
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Old 11-27-2011
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Correct Answer Got the answer!

IGF-1 and IGFBP-3 levels also decrease with aging. This decline of the GH–IGF-1 axis is probably caused by altered hypothalamic regulation (ie, decrease in GHRH and increase in somatostatin), rather than a decreased capacity to secrete GH.
The pathophysiology of the somatopause is confounded by several variables that can contribute to the decline in GH secretion associated with aging. These variables include the following:
  • Adiposity: Individuals who are moderately to markedly obese have profound suppression of GH secretion at any age.
  • Decreased production of sex steroid hormones: Falling levels of testosterone in men and estrogens in women affect GH secretion.
  • Decreased physical fitness: A strong correlation exists between aerobic capacity and 24-hour serum GH concentration.
  • Fragmented sleep: GH secretion can be affected by altered sleep patterns because it occurs predominantly during slow-wave sleep.
  • Malnutrition: Poor nutritional status negatively affects IGF-1 synthesis and action.
so since this old dude walks, he has a higher GH and hence IGF-1 .

So the answer is IGF-1 , congrats to all those who got it right, and all those who didn't( including ME) learning opportunityyy!
and thanks for posting the question MEANS ALOT!
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Quote:
Originally Posted by USMLE2011m View Post
IGF-1 and IGFBP-3 levels also decrease with aging. This decline of the GH–IGF-1 axis is probably caused by altered hypothalamic regulation (ie, decrease in GHRH and increase in somatostatin), rather than a decreased capacity to secrete GH.
The pathophysiology of the somatopause is confounded by several variables that can contribute to the decline in GH secretion associated with aging. These variables include the following:
  • Adiposity: Individuals who are moderately to markedly obese have profound suppression of GH secretion at any age.
  • Decreased production of sex steroid hormones: Falling levels of testosterone in men and estrogens in women affect GH secretion.
  • Decreased physical fitness: A strong correlation exists between aerobic capacity and 24-hour serum GH concentration.
  • Fragmented sleep: GH secretion can be affected by altered sleep patterns because it occurs predominantly during slow-wave sleep.
  • Malnutrition: Poor nutritional status negatively affects IGF-1 synthesis and action.
so since this old dude walks, he has a higher GH and hence IGF-1 .

So the answer is IGF-1 , congrats to all those who got it right, and all those who didn't( including ME) learning opportunityyy!
and thanks for posting the question MEANS ALOT!
Where you found the explanation?????????
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Where you found the explanation?????????
http://emedicine.medscape.com/article/126999-overview
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  #16  
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well to me,stress is not on the age,stress is on the exercise . .
if it's on the age why does he have normal BP?so exercises increases GH
by the way i hate it when some1 asks but doesn't tell what's the answer . .
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Quote:
Originally Posted by USMLE2011m View Post
Thanks......
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IGF higher for 50years old, the answer should be thyroo.
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Old 11-27-2011
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Read this article :

http://www.sciencedirect.com/science...67494308002367
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Old 11-28-2011
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all of u thanks for replying. but im sorry i dont know the answer myself. got this question in my exam. didnt know the answer so i thought why not ask everyone else. i answered IGF-1 btw.
thanks for the output.
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Old 11-28-2011
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Quote:
Originally Posted by legend View Post
all of u thanks for replying. but im sorry i dont know the answer myself. got this question in my exam. didnt know the answer so i thought why not ask everyone else. i answered IGF-1 btw.
thanks for the output.
hey legend, anymore questions???
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Old 11-29-2011
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yaa there is one more from behavoral, im about to post that too!!!
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