Something about Esterase - USMLE Forums
USMLE Forums Logo
USMLE Forums         Your Reliable USMLE Online Community     Members     Posts
USMLE Articles
Go Back   USMLE Forums > USMLE Step 1 Forum

USMLE Step 1 Forum USMLE Step 1 Discussion Forum: Let's talk about anything related to USMLE Step 1 exam

Thread Tools Search this Thread Display Modes
Old 05-25-2015
USMLE Forums Newbie
Steps History: 1+CK+CS
Posts: 3
Threads: 4
Thanked 0 Times in 0 Posts
Reputation: 10
Default Something about Esterase

Esterase is a hydrolase enzyme that makes esters to split into an acid and an alcohol within the human body. A hydrolase is an enzyme that catalyzes the hydrolysis of a chemical bond. When these two components are mixed with water, it is called hydrolysis. A broad range of various esterases exist that differ in their substrate (substrate is a molecule upon which an enzyme acts) specificity, their protein structure, and their biological function.

Esterases are a complex group of enzymes catalysing the hydrolysis of various organic esters. The multiplicity of esterases is wide and even the homologous tissues in different animals present a wide divergence in the heterogeneity of these enzyme forms.

Combining the relative mobility of the enzymes with substrate specificity and inhibitor sensitive characteristics, the multiple forms on a zymogram have been classified into carboxyl, aryl, acetyl and choline esterases 11. Employing similar procedures four more classes of esterases have been added to this list 4'5. Although the significance of esterases in phylogeny and comparative physiology has been emphasized 1, comparative survey of these enzymes in vertebrates has been limited to few species 8'11 only.

There are several kinds of esterase. Three factors set each type apart from the others: substrate specificity, biological function, and protein structure. Some types are found in lysozomes and are called acid hydrolase. Other types of esterase include Cholesterol esterase, Leukocyte esterase and Cholinesterase.

Leukocyte esterase is a urine test to look for white blood cells and other signs associated with infection.

Cholinesterase is widely used in clinical medicine. An absence or mutation of the pseudocholinesterase enzyme leads to a medical condition known as pseudocholinesterase deficiency. This is a silent condition that manifests itself only when people that have the deficiency receive the muscle relaxants succinylcholine or mivacurium during a surgery.
Pseudocholinesterase deficiency may also affect local anaesthetic selection in dental procedures. The enzyme plays an important role in the metabolism of ester-based local anaesthetics, a deficiency lowers the margin of safety and increases the risk of systemic effects with this type of anaesthetic. The selection of an amide-based solution is recommended in such patients.
Cholesterol esterase can be used to determinate the cholesterol in serum and plasma, with cholesterol oxidase or peroxidase and synthesize optically active alcohols and carboxylic acids (via ester hydrolysis, esterification, or transesterification)

Creative Enzymes provide Native Saccharomyces cerevisiae Esterase, Native Rhizopus oryzae Esterase, Native Rabbit Esterase, Native Porcine Esterase, etc.


45-16 Ramsey Road, Shirley, NY 11967, USA

Tel: 1-631-559-9269

Fax: 1-631-938-8127
Reply With Quote Quick reply to this message


Quick Reply

Register Now

In order to be able to post messages on the USMLE Forums forums, you must first register.
Please enter your desired user name, your email address and other required details in the form below.
User Name:
Please enter a password for your user account. Note that passwords are case-sensitive.
Confirm Password:
Email Address
Please enter a valid email address for yourself.
Email Address:
Medical School
Choose "---" if you don't want to tell. AMG for US & Canadian medical schools. IMG for all other medical schools.
USMLE Steps History
What steps finished! Example: 1+CK+CS+3 = Passed Step 1, Step 2 CK, Step 2 CS, and Step 3.

Choose "---" if you don't want to tell.

Favorite USMLE Books
What USMLE books you really think are useful. Leave blank if you don't want to tell.
Where you live. Leave blank if you don't want to tell.


Human Verification

In order to verify that you are a human and not a spam bot, please enter the answer into the following box below based on the instructions contained in the graphic.

Thread Tools Search this Thread
Search this Thread:

Advanced Search
Display Modes

Similar Threads
Thread Thread Starter Forum Replies Last Post
Ach esterase in Neural Tube Defects dr,maps USMLE Step 1 Forum 2 06-29-2013 08:51 AM
Peroxidase, alpha-naphthyl butyrate esterase and PAS Negative! m82_ghasemi USMLE Step 1 Forum 6 10-01-2011 06:25 PM
Acetyl Choline Esterase Level in amniotic fluid khushboo USMLE Step 1 Forum 2 05-25-2010 03:22 AM
Nitrite and Leukocyte Esterase in Urine andriaskansas USMLE Step 2 CK Forum 1 03-09-2010 11:55 AM

RSS Feed
Find Us on Facebook
vBulletin Security provided by vBSecurity v2.2.2 (Pro) - vBulletin Mods & Addons Copyright © 2016 DragonByte Technologies Ltd.

USMLE® & other trade marks belong to their respective owners, read full disclaimer
USMLE Forums created under Creative Commons 3.0 License. (2009-2014)