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Old 05-25-2015
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Default Something about Esterase

Esterase is a hydrolase enzyme that makes esters to split into an acid and an alcohol within the human body. A hydrolase is an enzyme that catalyzes the hydrolysis of a chemical bond. When these two components are mixed with water, it is called hydrolysis. A broad range of various esterases exist that differ in their substrate (substrate is a molecule upon which an enzyme acts) specificity, their protein structure, and their biological function.

Esterases are a complex group of enzymes catalysing the hydrolysis of various organic esters. The multiplicity of esterases is wide and even the homologous tissues in different animals present a wide divergence in the heterogeneity of these enzyme forms.

Combining the relative mobility of the enzymes with substrate specificity and inhibitor sensitive characteristics, the multiple forms on a zymogram have been classified into carboxyl, aryl, acetyl and choline esterases 11. Employing similar procedures four more classes of esterases have been added to this list 4'5. Although the significance of esterases in phylogeny and comparative physiology has been emphasized 1, comparative survey of these enzymes in vertebrates has been limited to few species 8'11 only.

There are several kinds of esterase. Three factors set each type apart from the others: substrate specificity, biological function, and protein structure. Some types are found in lysozomes and are called acid hydrolase. Other types of esterase include Cholesterol esterase, Leukocyte esterase and Cholinesterase.

Leukocyte esterase is a urine test to look for white blood cells and other signs associated with infection.

Cholinesterase is widely used in clinical medicine. An absence or mutation of the pseudocholinesterase enzyme leads to a medical condition known as pseudocholinesterase deficiency. This is a silent condition that manifests itself only when people that have the deficiency receive the muscle relaxants succinylcholine or mivacurium during a surgery.
Pseudocholinesterase deficiency may also affect local anaesthetic selection in dental procedures. The enzyme plays an important role in the metabolism of ester-based local anaesthetics, a deficiency lowers the margin of safety and increases the risk of systemic effects with this type of anaesthetic. The selection of an amide-based solution is recommended in such patients.
Cholesterol esterase can be used to determinate the cholesterol in serum and plasma, with cholesterol oxidase or peroxidase and synthesize optically active alcohols and carboxylic acids (via ester hydrolysis, esterification, or transesterification)

Creative Enzymes provide Native Saccharomyces cerevisiae Esterase, Native Rhizopus oryzae Esterase, Native Rabbit Esterase, Native Porcine Esterase, etc.


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