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Old 12-02-2011
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Question Proximal and facial muscle weakness

32 yr old woman with dysphagia and facial and proximal muscle weakness and normal reflexes, sensation and coordination. Which drug has to be avoided in her case?

a. Penicillin
b. Propylthiouracil
c. Metformin
d. Beta blocker
e. Statin

Post answer with explanation
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Old 12-03-2011
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i think answer should be E.......statins cause myopathy and they will exaggerate this woman's muscle weakness..........!!!
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Old 12-03-2011
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I think statin should be avoided ...causes myopathy
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Old 12-03-2011
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as all cns sign sem normal the prob is myopathic
so aviod drugs exagerating this prob so ill go wit statins...
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Old 12-03-2011
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the case is of Myasthenia gravis,note the facial muscle weakness with dysphagia,also proximal muscle weakness.

So the answer is d. beta blockers. Although I cannot understand why beta blockers not used In myasthenia
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Old 12-03-2011
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Quote:
Originally Posted by indigo View Post
the case is of Myasthenia gravis,note the facial muscle weakness with dysphagia,also proximal muscle weakness.

So the answer is d. beta blockers. Although I cannot understand why beta blockers not used In myasthenia
where'd u get this question from?

Rx of MG is done via anti-cholinesterases... how is B-blocker c/i in these patients, I am having difficulty clicking it
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Old 12-03-2011
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Quote:
Originally Posted by USMLE2011m View Post
where'd u get this question from?

Rx of MG is done via anti-cholinesterases... how is B-blocker c/i in these patients, I am having difficulty clicking it
This is a Kaplan question although I myself dunno why beta blocker CI in MG even Goljan also says so without any explanations
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Old 12-03-2011
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Why not metformin?
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Old 12-03-2011
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myasthenia gravis is caused due to antibodies direscted towards Ach receptors. so the disease has no relation with beta receptors.
beta blocker is C/I may b becoz of its one of common sideeffect, tremor and the affect of beta receptors in gylcogenolysis in muscles.
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Old 03-02-2013
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Default beta blocker

beta blocker increase further weakness b/c (normaly it cause glycogenolysis , glyconeogenesis by stimulting beta blocker) bt whn u gve beta blocker dec glucose lead to furthr weakness.... plz correct if i m wrong.....
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