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Old 12-04-2011
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Syringe Live versus Killed vaccine immune response

Two patients are vaccinated against poliomyelitis. One patient receives the killed vaccine and the other patient receives the live attenuated vaccine. One month after the vaccination, the levels of which of the following poliovirus antibodies will differ most between these patients?

A. Serum IgM
B. Serum IgG
C. Serum IgA
D. Cerebrospinal fluid IgG
E. Duodenal IgA


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Old 12-04-2011
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Serum IgA ..
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Serum IgA
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i think duodenal IgA..............
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Old 12-04-2011
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Correct Answer Answer is duodenal IgA

One general principle of vaccination dictates that local secretory antibody synthesis is best promoted when specific mucosal surfaces are directly stimulated by antigen. When both live and killed vaccines are applied to a mucosal surface, the live attenuated viral vaccines appear more effective of the two in generating prolonged mucosal IgA secretion. The live vaccines are thought to colonize the natural site of viral entry, producing a greater and more prolonged immune response there. Killed viral vaccines (which are usually administered intramuscularly) are unable to stimulate mucosal secretory lgA production. In the case of the polio vaccines the intramuscularly-given Salk formaldehyde-inactivated polio vaccine (IPV) is less effective in generating a prolonged nasopharyngeal and intestinal mucosal secretory IgA response than is the Sabin live attenuated oral polio vaccine (OPV).
(Choices A, B, and D) The antibody most strongly associated with antigenic mucosal contact is IgA, not lgG or 1gM.
(Choice C) The two sites of primary poliovirus replication (and associated mucosal IgA secretion) are the oropharynx and intestine. The serum IgA levels appear less impacted by vaccination.

Educational Objective:
When a live attenuated vaccine (eg, the Sabin oral polio vaccine) is applied to mucosal surfaces, it appears to promote more prolonged synthesis and secretion of local mucosal IgA than does a killed vaccine (eg, the Salk inactivated polio vaccine). This increase in mucosal IgA offers immune protection at the normal site of viral entry.
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Old 12-05-2011
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What will be the difference in antibody levels if a killed and live attenuated vaccine are given intramusculary?

Will the heat killed vaccine produce only Igm and the live attenuated produce both IgG and IgM.?

Had this doubt after reading this question.
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