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#1
12-05-2011
 USMLE Forums Master Steps History: 1+CK+CS+3 Posts: 623 Threads: 111 Thanked 424 Times in 264 Posts Reputation: 434
Calculating the carrier frequency in a population!

Cystic fibrosis is an autosomal recessive disease, if the incidence of disease in white population is 1/2500, then which of the following is appropriate carrier frequency of this Mendelian trait in this population ???????

a) 1/12
b) 1/25
c) 1/50
d) 1/125
e) 1/625

 The above post was thanked by: doxorubicin (12-07-2011), riya10 (12-07-2011)

#2
12-05-2011
 USMLE Forums Veteran Steps History: Not yet Posts: 281 Threads: 74 Thanked 132 Times in 69 Posts Reputation: 142

1/25 as q squared is 1/2500 so q will be 1/50 and 2pq assuming p=1 is 1/25.
Am i correct
 The above post was thanked by: aknz (12-05-2011), riya10 (12-07-2011), Step-step (08-18-2012)
#3
12-07-2011
 USMLE Forums Addict Steps History: Not yet Posts: 124 Threads: 13 Thanked 60 Times in 43 Posts Reputation: 70

Quote:
 Originally Posted by indigo 1/25 as q squared is 1/2500 so q will be 1/50 and 2pq assuming p=1 is 1/25. Am i correct
will you explain it plz?????
thanx

#4
12-07-2011
 USMLE Forums Addict Steps History: Not yet Posts: 124 Threads: 13 Thanked 60 Times in 43 Posts Reputation: 70

Quote:
 Originally Posted by indigo 1/25 as q squared is 1/2500 so q will be 1/50 and 2pq assuming p=1 is 1/25. Am i correct
ok..ok.... i got it!!!!!
 The above post was thanked by: indigo (12-07-2011)
#5
12-07-2011
 USMLE Forums Guru Steps History: Step 1 Only Posts: 342 Threads: 50 Thanked 197 Times in 103 Posts Reputation: 207

is it incidence of disease or prevalence of disease? ? ?
 The above post was thanked by: aknz (12-07-2011)
#6
12-07-2011
 USMLE Forums Master Steps History: 1+CK+CS+3 Posts: 623 Threads: 111 Thanked 424 Times in 264 Posts Reputation: 434

Quote:
 Originally Posted by zohaib is it incidence of disease or prevalence of disease? ? ?
In Q,we have to find the heterozygote prevalence 2pq.

It is the prevalence of disease.
#7
12-07-2011
 USMLE Forums Master Steps History: 1+CK+CS+3 Posts: 623 Threads: 111 Thanked 424 Times in 264 Posts Reputation: 434

Quote:
 Originally Posted by indigo 1/25 as q squared is 1/2500 so q will be 1/50 and 2pq assuming p=1 is 1/25. Am i correct

1/25
#8
12-07-2011
 USMLE Forums Guru Steps History: Step 1 Only Posts: 342 Threads: 50 Thanked 197 Times in 103 Posts Reputation: 207

Quote:
 Originally Posted by aknz In Q,we have to find the heterozygote prevalence 2pq. It is the prevalence of disease.
no,no no,, actually i asked 1/2500 is incidence or prevalence of disease . . ?

 Tags Biostatistics-Epidemiology, Genetics-, Step-1-Questions

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