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Old 06-01-2015
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Unhappy VDJ in Immunology

HI
CAN ANYONE EXPLAIN THE WHOLE CONCEPT OF "VDJ AND LIGHT CHAINS, ETC.
HOW WOULD THIS BE ASKED?

ANY EXPLANATION OR POINTERS WOULD BE APPRECIATED!
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Old 06-02-2015
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First of all Look at this schematics:




This is the normal VDJ recombination that occurs

Now take a look at this:




See this is class switching here the constant region is also cut and modified...so that now we can form IgG instead of IgM


and too sum it all up here is a Mnemonic by rasheed - Original Post

Quote:
Originally Posted by rasheed
The DNA rearrangements that is responsible for the diversity of the lymphocyte receptor specificity and idiotypic antigenicity produced by the V, D, and J DNA segments.
Always forgetting which is which? Here's a mnemonic
VDJ = more genes = Bigger (heavy) chain of the immunoglobuline variable redgion and Beta chain of the TCR
VJ = less genes = light chain of the immunoglobuline = alpha chain of the TCR

Hope that helps
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