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Old 06-03-2015
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Default Graft vs host disease

In the Kaplan lecture, they said that people with CD 4 + T cells deficiency won't get GVHD..e.g. Ppl with aids, Digeorges syndrome, SCID..

Can anyone plz explain why these patients won't get gvhd if they receive bone marrow transplant? Cuz isn't it that the (donor) grafted immunocompetent T cells attack host MHCs leading to damage.
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Old 06-03-2015
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Default Hello Samusmle

if you have FA read pg 214 year 2014
It says
Graft immunocompetent T cells proliferate in the immunocompromised HOST and REJECT host cells with foreign bodies...
In reality seems like bone marrow transplant for leukemia /graft versus tumor effect it would be beneficial.
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Old 06-03-2015
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Default Mmmm.. Let's see

for GVHD to occur you need:
Immunocompetent graft given to the recipient (graft with function T cells)
Immunocompromised CANNoT destroy the grafted T Cells... ( there's NO GVHD

Graft versus host disease happens when...
The transplanted bone marrow has TCells attack the recipient tissues that are immunocompromised. So AIDS, SCID, Di George are perfect victims of GVHD.

Don't forget
GVHD can be seen in solid organs such as liver transplant which is part of a lymphoreticular system and may contain T cells.

I hope it helps...
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Old 06-03-2015
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Default

Thx...yeah that's what I thought too
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