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  #1  
Old 06-04-2015
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Default Testicular feminization syndrome

In TFS, the androgen receptors are defective. The genotype is XY; testes are present(cuz of TDF) but undescended; male internal structures (Seminal vesicles, epididymyis, ejac ducts, and ductus deferens) are also present. External genitalia are female.

My question is: Do wolfian ducts require testosterone for dev of male internal structures?

If androgen RECs are defective in Testicular feminization syndrome, the wolfian ducts shouldn't differentiate into male internal structures?
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Old 06-04-2015
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Quote:
Originally Posted by samusmle33 View Post
In TFS, the androgen receptors are defective. The genotype is XY; testes are present(cuz of TDF) but undescended; male internal structures (Seminal vesicles, epididymyis, ejac ducts, and ductus deferens) are also present. External genitalia are female.

My question is: Do wolfian ducts require testosterone for dev of male internal structures?

If androgen RECs are defective in Testicular feminization syndrome, the wolfian ducts shouldn't differentiate into male internal structures?
yes testosterone is required by wolfian duct to make internal structures. And testosterone converts to DHT and makes external structures.
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Old 06-04-2015
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There's no clear answer yet in research, most mechanism are hypothesized. This study over here concludes "These findings provide the first evidence that androgens may not be the only factor involved in determining WD fate. Other factors may promote survival of the WD in males or actively promote WD regression in females, suggesting sexually dimorphic differences in the preprogrammed setup of the WD."
http://www.ncbi.nlm.nih.gov/pubmed/19131576
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Old 06-04-2015
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Right..thx guys! Appreciate your input.

So v can say tht despite defective androgen receptors in test feminization syndrome, the wolfian ducts develop into male internal structures in the presence of testosterone AND some other factors.
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