D-Dimer And FDP - USMLE Forums
USMLE Forums Logo
USMLE Forums         Your Reliable USMLE Online Community     Members     Posts
USMLE Articles
Go Back   USMLE Forums > USMLE Step 1 Forum

USMLE Step 1 Forum USMLE Step 1 Discussion Forum: Let's talk about anything related to USMLE Step 1 exam

Thread Tools Search this Thread Display Modes
Old 12-07-2011
callmerocky2's Avatar
USMLE Forums Addict
Steps History: 1+CK+CS
Posts: 187
Threads: 28
Thanked 101 Times in 56 Posts
Reputation: 111
Blood D-Dimer And FDP

Can someone pls temme what D-dimer and FDP are and their use?
Reply With Quote Quick reply to this message
The above post was thanked by:
riya_rai84 (12-11-2011)

Old 12-11-2011
USMLE Forums Scout
Steps History: Not yet
Posts: 85
Threads: 13
Thanked 32 Times in 21 Posts
Reputation: 42

Fibrinogen, and fibrin degradation products

Fibrinogen is a circulating plasma protein manufactured by the liver. Thrombin converts fibrinogen to fibrin in the final stage of blood coagulation. Low fibrinogen levels can occur as a result of severe liver disease or due to a disorder such as disseminated intravascular coagulation (DIC). Fibrinogen is quantified by adding thrombin to a series of successively more dilute plasma samples and comparing clotting time to a control series. A coagulation analyzer is used to determine clotting time which will be inversely proportional to the concentration of fibrinogen. Normal values are approximately 200-400 mg/dl. Fibrinogen can also be measured directly by immunoassay. In this test a fibrinogen antibody is added to a plasma sample and then fibrinogen marked with the antibody is measured.

Fibrin degradation products (FDP), also known as fibrin slpit products, are present in blood when the thrombolytic enzyme plasmin cleaves fibrin or fibrinogen. Plasmin is produced when the thrombolytic system is activated. D-dimers are an FDP produced when fibrin is cleaved by plasmin. The presence of D-dimers or FDP may be used to assist with the diagnosis of DIC, Deep Venous Thrombosis (DVT) or Pulmonary Embolism (PE). However, because they are produced under a variety of circumstances their presence alone is not diagnostic.

Reply With Quote Quick reply to this message
The above post was thanked by:
callmerocky2 (12-11-2011), Dr.ion (01-26-2016)



Quick Reply

Register Now

In order to be able to post messages on the USMLE Forums forums, you must first register.
Please enter your desired user name, your email address and other required details in the form below.
User Name:
Please enter a password for your user account. Note that passwords are case-sensitive.
Confirm Password:
Email Address
Please enter a valid email address for yourself.
Email Address:
Medical School
Choose "---" if you don't want to tell. AMG for US & Canadian medical schools. IMG for all other medical schools.
USMLE Steps History
What steps finished! Example: 1+CK+CS+3 = Passed Step 1, Step 2 CK, Step 2 CS, and Step 3.

Choose "---" if you don't want to tell.

Favorite USMLE Books
What USMLE books you really think are useful. Leave blank if you don't want to tell.
Where you live. Leave blank if you don't want to tell.


Human Verification

In order to verify that you are a human and not a spam bot, please enter the answer into the following box below based on the instructions contained in the graphic.

Thread Tools Search this Thread
Search this Thread:

Advanced Search
Display Modes

RSS Feed
Find Us on Facebook
vBulletin Security provided by vBSecurity v2.2.2 (Pro) - vBulletin Mods & Addons Copyright © 2016 DragonByte Technologies Ltd.

USMLE® & other trade marks belong to their respective owners, read full disclaimer
USMLE Forums created under Creative Commons 3.0 License. (2009-2014)