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Old 06-08-2015
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Default nonmegaloblastic macrocytic anemia

Can someone please explain why we get nonmegaloblastic macrocytic anemia from liver disease, alcohol, hypothyroidism, and reticulocytosis

thanks.
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Old 06-08-2015
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Originally Posted by yagoy View Post
Can someone please explain why we get nonmegaloblastic macrocytic anemia from liver disease, alcohol, hypothyroidism, and reticulocytosis

thanks.
1. Nonmegaloblastic - we dont have defect in production of RBC in bone marrow(no Megaloblasts). We need B12 and B9(deficiency of which is leading to MM anemia) for nucleus maturation. but nucleus cannot maturate(condense and fall off in this situation) so in Bone marrow we see really big precursors of RBC with big nucleus(that cannot fall off because of deficiency of b12-b9)

2. Macrocytic - most of the RBC are more than 100 femtoliter
Why we have MM anemia in reticulocytosis?(hemolytic anemia and so on)
Because while differention of RBC, precursors of RBC dividing and making next cells smaller and smaller with each division. So reticulocytes slightly bigger than erythrocytes, because they are not mature enough

3. Liver disease can lead to target cells(which have larger surface so - macrocytic)

4. Alchohol - toxic effect on liver - 3

5. Hypothyroidism - dunno
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