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Old 12-13-2011
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Psyche Diferential Diagnoses of Dementia

I got a little confused with Pick, Lewy, Huntington and Wilson's disease since those have very similar symptoms. Can anybody give me some advice or some key words of them? Thanks!
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May be this simply put random facts may help you buddy:
Alzheimer's: Most common in elderly
Parkinsons's: Destruction of dopaminergic neurons in Substantia Nigra
Pick's: Silver stain, Aphasia
Lewy: Visual hallucinations along with Parkinsonism and dementia
Wilson's: Kayser-Fleicher rings in eye, AR, Hepatolenticular degeneration
Huntington's: Chorea, Trinucleotide repeat disorder
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Old 12-13-2011
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Also read this useful post here
List of possible dementia clinical scenarios in USMLE

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picks is always frontal-temporal lobe involvement so clinically we see behaviour or personality changes.
huntington thts involvement of caudate nucleus so chorea or flinging movements is char
wilsons is basal ganglia involving putamen so case might describe patient copper deposition in cornea kayser rings,some abnormal movements due basal ganglia deposition of cu.
lewy body thts parkinsons so we have rigidity,akinesia,hypotonia,mask like facies.severity of symptoms depending on destruction of subs nigra.
so along with dementia we see some additional symptoms char to each.
alziemers thts progressive old age,neurofibrillary tangles amyliod plaques.
hope this helps!
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