Sequence of events in Hypersentivity type 1 reaction - USMLE Forums
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Old 12-17-2011
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Immunology Sequence of events in Hypersentivity type 1 reaction

1. Degranulation of mast cells and basophils occurs when allergen binds to two adjacent IgE antibodies on the membrane of the cell
2. Interleukin 4 released by CD4 helper T cells causes activated B cells to switch from making IgM to IgE
3. Processed allergen is associated with a class II molecule on an antigen presenting cell and recognized by CD4+ TH2 cells
4. Prostaglandins and leukotrienes are released
5. The allergen is phagocytized and processed by a macrophage or a dendritic cell
Based on the numbered list above, which of the following is the correct sequence of events in the Type I hypersensitivity reaction?
A. 1,2,3,5,4
B. 1,4,3,5,2
C. 1,5,2,3,4
D. 5,3,1,4,2
E. 5,3,2,1,4
Explanation:


That's a good question guy,if you got it in your test it gonna be take a long of time to contest it
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  #2  
Old 12-17-2011
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Because... 5,3 and 2 are the steps of sensibilisation that occur after exposing to any given allergen (Mmm... lets say pollen) in an "X" patient, lets call him "Pepito". Then, "1" is the part when "Pepito" smells pollen again and "4" (I'm guessing) is the part when our dear old friend "Pepito" is in the way of developing an anaphylactic reaction.
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Old 12-17-2011
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yup answer is E.........
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Old 12-17-2011
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E ) 5,3,2,1,4
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