Why afferent arteriole contriction does not affect filtration fraction! - USMLE Forums
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Old 12-21-2011
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Kidney Why afferent arteriole contriction does not affect filtration fraction!

hi guys!
i have confusion, want to clear it....
if renal plasma flow goes down then FF will goes up.
dr. Dunn says... in lots of pressure, lots of tension therefore, if flow goes down then FF will goes up. and if flow increases then FF will decreases.
my Ques is how it comes that during Afferent constriction there is no change in FF. WHY??????
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Old 12-21-2011
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Filtration fraction (FF)=GFR/RPF

now when afferent arteriole constricts both RPF and GFR reduce in the same proportion so the ratio remains same i.e FF.

u can only understand it best when u look at the diagram first aid(2011) pg 460 .

also remember Prostaglandins dilate afferent arteriole -very high yield
and AT II constricts efferent arteriole.

hope it helps.
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Old 12-21-2011
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Correct Answer

thanx a lot!! now i got it......
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Old 12-22-2011
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just to make it easy my doctor at college uses the term medical nephrectomy
in giving a pt NSAID +ACEI u inhibit pge2 and ace
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