Methacholine Challange Test; Asthma versus COPD - USMLE Forums
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Old 12-21-2011
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Lungs

I need to clarify if I am understanding right

In asthma it won't reverse (or will require more of the drug to reverse) vs another COPD?

I'm refering to the - methacholine challenge test
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Old 12-22-2011
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Default Useful concepts:

I think you are mixing up some concepts here.

Here are the facts:

Reversibility of obstruction (bronchodilator response)
Asthma is characterized by reversibility of bronchoconstriction after the use of beta 2 agonist (bronchodilator). Patients with COPD, do not reverse their bronchoconstriction because it's more inflammatory rather than just smooth muscle constriction.

Bronchoprovocation testing (e.g. Methacholine challenge test)
This is used to diagnose difficult cases of asthma (or to predict future asthma development). It's positive in asthma patients but it can also be false positive in COPD patients.

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Old 12-22-2011
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Default

Thanks,
Good explanation clarified concepts to me
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