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  #1  
Old 12-22-2011
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Help Di george syndrome clinical features

In Di George syndrome would there be a mediastinal widening or narrowing on Chest X ray?

Also what would the immunoglobulin levels? increased or decreased or normal?

Please help me understand this :sorry:
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  #2  
Old 12-22-2011
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I think absent thymic shadow on CXR.

Immunoglobulins IgG, E, A will be less because class switching cannot happen.

NB: Thymoma is Associated with Myesthenia Gravis
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Old 12-22-2011
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normal immunoglobulin levels according to first aid q &A
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Old 12-22-2011
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Quote:
Originally Posted by yazz View Post
normal immunoglobulin levels according to first aid q &A
Yeah the correct ans is normal levels of Immunoglobulins but i thought T cells responsible for class switching so did not understand.
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Quote:
Originally Posted by deeqwerty View Post
I think absent thymic shadow on CXR.

Immunoglobulins IgG, E, A will be less because class switching cannot happen.

NB: Thymoma is Associated with Myesthenia Gravis
Doesn't the size of thymus increase in thymoma? Should that not increase the thymic shadow?
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Old 12-22-2011
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Quote:
Originally Posted by indigo View Post
Yeah the correct ans is normal levels of Immunoglobulins but i thought T cells responsible for class switching so did not understand.

Thanks.

But hypogammaglobulinemia can happen. Though Rarely. UW qid 1995
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Old 12-22-2011
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Quote:
Originally Posted by indigo View Post
Doesn't the size of thymus increase in thymoma? Should that not increase the thymic shadow?
I think it should. And if it is large enough you will see mediastinal widening also.
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Quote:
Originally Posted by deeqwerty View Post
I think it should. And if it is large enough you will see mediastinal widening also.
So will there be absence of thymic shadow?
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Old 12-22-2011
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DiGeorge syndrome

Thymic aplasia -absent thymic shadow on CXR

(its not a thymoma its aplasia i.e thymus fail to develop due 22q11 deletion, failure to develop 3rd and 4th pharyngeal pouches, its congenital disorder)

no thymus so no T cells.(recurrent viral n fungal infx)

no T helper cells so immunoglobulins cannot class switch so IgM normal rest all deff i.e IgE IgA IgG deff

also parathyroid fail to develop coz it develops from 3rd and 4th pharyngeal pouches -so hypocalcemia -Tetany

SO remember 3rd and 4th pharyngeal pocuh fail to develop rest all is down hill

hope it helps
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Thanks man, I was completely missing the point.
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  #11  
Old 12-22-2011
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btw this questions was it from a bank? which one if it was?
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