Membranoproliferative Glomerulonephritis versus Membranous Glomerulonephritis - USMLE Forums
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Old 12-22-2011
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Kidney Membranoproliferative Glomerulonephritis versus Membranous Glomerulonephritis

Can any one explain MPGN (membranoproliferative glomerulonephritis) is it nephritic or nephrotic and is it the cause for SLE
and also is it the same as membranous glomerulonephritis??
I read it in FA and really get confused and cant differentiate them?
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Old 12-22-2011
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MPGN two types type 1 nephritic and type 2 is nephrotic simple and former one is tram track associated and later one is dense deposit disease MPGN is associated with so many diseases like HCV Etc and just remember in SLE most common is type 4 memberanous glomerulonrphritis which is nephritic ( its different from MPGN , MPGN is tottaly different thing )
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Old 12-25-2011
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Default MPGN

MPGN presentation is commonly nephritic. Lupus nephritis, depending on which subtype, can be nephritic (eg. Lupus class 3 or 4, or focal proliferative or diffuse proliferative lupus nephritis, respectively), or nephrotic (eg lupus class 5, also known as membranous lupus nephritis). Membranous nephropathy almost always present as nephrotic, with marked proteinuria. The differences between these glomerulopathies resides in where the electron dense deposits are seen on electron microscopy. In the case of membranous glomerulopathy, and also in the case of membranous lupus, the deposits are sub epithelial (between the glomerular basement membrane and podocytes). in the case of MPGN, and class 3 and 4 proliferative lupus nephritis, the deposits are sub endothelial (between the gbm and endothelial cell in glomerular capillaries). In MPGN, the deposits stain mainly for complement C3, and variably for immunoglobulins. In the case of lupus, the deposits will stain for complements C3, C1q and usually for all immunoglobulins, especially for IgG, but also for IgM and or IgA, kappa and lambda light chains (that is what the "full house" pattern of staining). Pure membranous glomerulopathy typically only staid for IgG and C3.
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Old 12-25-2011
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Correct Answer MPGN vs Membranous vs Lupus

MPGN presentation is commonly nephritic. Lupus nephritis, depending on which subtype, can be nephritic (eg. Lupus class 3 or 4, or focal proliferative or diffuse proliferative lupus nephritis, respectively), or nephrotic (eg lupus class 5, also known as membranous lupus nephritis). Membranous nephropathy almost always present as nephrotic, with marked proteinuria. The differences between these glomerulopathies resides in where the electron dense deposits are seen on electron microscopy. In the case of membranous glomerulopathy, and also in the case of membranous lupus, the deposits are sub epithelial (between the glomerular basement membrane and podocytes). in the case of MPGN, and class 3 and 4 proliferative lupus nephritis, the deposits are sub endothelial (between the gbm and endothelial cell in glomerular capillaries). In MPGN, the deposits stain mainly for complement C3, and variably for immunoglobulins. In the case of lupus, the deposits will stain for complements C3, C1q and usually for all immunoglobulins, especially for IgG, but also for IgM and or IgA, kappa and lambda light chains (that is what the "full house" pattern of staining). Pure membranous glomerulopathy typically only staid for IgG and C3.[/QUOTE]
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