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#1
12-23-2011
 USMLE Forums Addict Steps History: Not yet Posts: 140 Threads: 52 Thanked 14 Times in 12 Posts Reputation: 24
P50 and O2 Hb dissociation curve

hi
I just cant find why increase in P50 lead to curve diccociation to the right??

#2
12-23-2011
 USMLE Forums Scout Steps History: Not yet Posts: 46 Threads: 3 Thanked 34 Times in 20 Posts Reputation: 44

1. What is P50?

• P50 is the partial pressure at which arterial O2 saturation is at 50%

2. What are the axis for the oxygen-haemoglobin dissociation curve?

• The y-axis is the saturation
• The x-axis is the partial pressure of O2

3. What does an increased P50 mean?

• It means that a greater partial pressure of O2 is required to maintain a saturation of 50%
• Take the normal O2-Hb dissociation curve and draw a horizontal line at 50% saturation. If the partial pressure corresponding to this saturation is increased does that mean a left or right shift of the curve?
• Right-shift!
 The above post was thanked by: Hamada (08-16-2014), riya10 (12-23-2011), sibb (12-24-2011), VVDieiev (07-11-2014)

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