Onion-Like Femoral Tumor Genetic Mutation! - USMLE Forums
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Old 12-28-2011
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Bones Onion-Like Femoral Tumor Genetic Mutation!

An 11-year-old boy complains of pain in his left leg with no history of prior trauma. The pain is not relieved by acetaminophen and slowly progresses. Radiographic examination shows a femoral tumor with an "onion-skin" pattern of circumferential reactive periosteal bone. Examination of biopsy material stained with hematoxylin and eosin reveals small uniform blue round cells. On the basis of this information, which of the following is the most likely genetic mutation?

A. del 1p
B. t(2,13)
C. t(11,22)
D. t(12,22)
E. t(X,18)
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Old 12-28-2011
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C. t(11,22) Ewing's sarcoma
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Old 12-28-2011
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I also thought Ewing from clinical,,but its mutation is 11 33 I guess...
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Old 12-28-2011
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answer is c
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t(11,22) - ewing's sarcoma
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C. t(11,22)
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Old 12-29-2011
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The answer is C.

This is the chromosomal mutation for Ewing sarcoma. This case demonstrates the typical presentation of Ewing sarcoma, occurring mainly in the long bones of children and adolescents. It presents with pain and has a unique onion-skin effect on x- ray. Histologically, it is known as a small, round, blue-cell tumor. A number of different tumors look similar, and molecular methods are increasingly used for diagnosis.
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