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Old 12-29-2011
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Neuro Why low glucose and high protein in meningitis CSF

I have a conceptual question why does protein increase in CSF in meningitis whereas glucose amount decreases

-Whosoever answer these question plz do consult good books, as I really myself don't recall the answer to this question,

please ASAP thnx
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Old 12-29-2011
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Default hi

It's an inflammatory process in response to microorganism, if bacterial we suppose that the bacteria consume the CSF glucose, while the influx of CSF and the ensuing increased vascular permeability allows proteins to leak into the CSF.
If viral we suppose that they dont consume glucose so much so the glucose levels are near normal. I suppose that the influx of WBC also contribute to the rise in proteins, are cells considered proteinacous?
I am sorry I didn't follow your instruction to check the books.
Hopefully some who is sure will post a reply
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Old 12-29-2011
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Assessment of CSF protein level, while nonspecific, can be a clue to otherwise unsuspected neurologic disease. The high protein levels in demyelinating polyneuropathies, or postinfectious states, can be informative. A traumatic tap can introduce protein into the CSF. An approximation of 1 mg of protein per 750 RBCs may be used, but a repeat tap is preferable.

The CSF glucose level normally approximates 60% of the peripheral blood glucose level at the time of the tap. A simultaneous measurement of blood glucose (especially if the CSF glucose level is likely to be low) is recommended. A low CSF glucose level is usually associated with bacterial infection (probably due to enzymatic inhibition rather than actual bacterial consumption of the glucose). This finding is also seen in tumor infiltration and may be one of the hallmarks of meningeal carcinomatosis, even with negative cytologic findings. A high CSF glucose level has no specific diagnostic significance and is most often spillover from an elevated blood glucose level.

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