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Old 06-25-2015
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Question Question on Antithrombin Deficiency

According to FA2015 pg398, antithrombin deficienty should have a normal PT&PTT, and an under-responsiveness to heparin.
I'm wondering why the PT&PTT are normal in antithrombin deficienty. Could anyone give some idea?
Thanks in advance!
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Old 06-26-2015
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Antithrombin 3 (Heparin like molecule-anticoug) has the function normally to inactivate thrombin(II) and factor X, if is deficient PTT and PT doesn't have to be alter but this increase the risk of thrombosis because the physiologic balance btw of procoagulation and anticoag is loss.
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Old 06-26-2015
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We do pt ptt in the labs... Where antithrombin iii is of no use... But in the body it might predispose to thrombosis... Pt ptt will only vary when the factor levels vary but here the factors are in excess that too in the body so pt ptt won't vary... Excess factor might predispose to thrombosis
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