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Old 12-29-2011
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Microscope Dying epithelial cells in crypts showing fragmented nuclei

A gastric biopsy is performed on a patient with suspected graft-versus-host disease following bone marrow transplantation. The biopsy demonstrates many isolated dying epithelial cells in crypts showing fragmented, hyperchromatic nuclei and small discrete blebs containing both cytoplasm and nuclear fragments. The biopsy demonstrates which of the following?

A. Apoptosis
B. Caseous neurosis
C. Coagulative necrosis
D. Gangrenous necrosis
E. Liquefactive necrosis
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I think its apoptosis. GVHD, cells of the donor will kill the epethelial cells
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A. coz GVHD T cells (graft's) proliferate and reject host cells.and the way T cells kill is apoptosis

its a guess.lets see
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A. Apoptosis...! Small discrete blebs appear in apoptosis that are phagocytosed by the neighbouring epithelial and phagocytic cells!! beside that graft T cells attacks the host cells in skin, GIT and Billiary tract producing Dermatitis, bloody Diarrhea and Jaundice!!
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its a.apoptosis
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its apoptosis
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seems Apoptosis
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A apoptosis
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y not C. . ..
it's not programmed cell death so it's not A
you should mention time between graft implantation and GVHD . .
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The answer is A.

The changes described are those of apoptosis, which is a form of programmed cell death. Apoptosis can be seen in a variety of settings. In this case, it is occurring in the context of graft-versus-host disease, which is mediated by CD8+ and CD4+ cells. Apoptosis also occurs during embryogenesis, during hormone-dependent involution in the adult (eg, during menstruation), during rapid proliferation of cell populations (eg, intestinal crypt epithelia), and in the immune system (e.g., in developing thymus). It can also occur after duct obstruction in organs such as pancreas and during some viral diseases. The hallmark of this programmed method of cell death is the fragmentation of the cell with formation of cytoplasmic blebs and apoptotic bodies that are phagocytized by other healthy cells.
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Quote:
Originally Posted by zohaib View Post
y not C. . ..
it's not programmed cell death so it's not A
you should mention time between graft implantation and GVHD . .

look at the "orderly" fashion described here - dna condensing, i.e the hyperchromatic nucleus; the neat organization of cytoplasm into blebs so that nothing spills over; thats apoptosis
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