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Old 12-30-2011
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RBC Anemia of chronic disease and TIBC

plz somebody explain y do TIBC and % saturation decreased while ferritin level increased in AOCD. .
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Old 12-30-2011
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hepicidin - keeps iron in macrophages. so u store more. as a result, TIBC goes down, cause u alrdy have alot of iron and dont need any, along the same lines theres less iron in ure plasma cause its in macrophages so the % sat. goes down

hope that helps.
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Old 12-30-2011
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Chronic disease reuslts in increase of acute phase reactants and hepcidin

hepcidin sequesters iron in storage sites by - limiting iron transfer from macrophage to eryhtroid precursors.

(sequesters means hide away or isolate)

aim is to prevent bacteria from accessing iron which is necessary to their survival.

So iron present in storage sites so ferritin increase.but iron cannot be used for erythroid precursors so TIBC decrease(TIBC measures transferrin in blood)

%sat decreased coz it measures %transferrin that are bound by iron.
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