APUD, S 100 and synaptophysin and neuroendocrine tumors! - USMLE Forums
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Old 01-01-2012
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Question APUD, S 100 and synaptophysin and neuroendocrine tumors!

Happy new year guys,

Could someone explain the terms APUD, S 100 and synaptophysin in relation to neuro endocrine tumors?
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Old 01-01-2012
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Happy new yr mate
I will just tell you whatever I know you about them I hope it helps you
APUD tumors-Refers to all the neuroendocrine tumors
Synaptophysin is the gene located on short arm of x chromosome and is marker for all APUD tumors
S100-Its a protien for which there is a specific stain called S100 nw they are present in all cell which are neural crest in origin.
Some of APUD tumors are found positive for both synaptophysin and S100 as they are also neural crest in origin fr eg-melanoma, small cc, carcinoid, neuroblastoma in adrenal medulla
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Old 01-01-2012
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Correct Answer

Quote:
Originally Posted by mohitkmc View Post
Happy new yr mate
I will just tell you whatever I know you about them I hope it helps you
APUD tumors-Refers to all the neuroendocrine tumors
Synaptophysin is the gene located on short arm of x chromosome and is marker for all APUD tumors
S100-Its a protien for which there is a specific stain called S100 nw they are present in all cell which are neural crest in origin.
Some of APUD tumors are found positive for both synaptophysin and S100 as they are also neural crest in origin fr eg-melanoma, small cc, carcinoid, neuroblastoma in adrenal medulla
I agree with most of what u said except 2 things
APUD is Amine Precursor Uptake and Decarboxylation tumors.
Synaptophysin is a transmembrane glycoprotein found in the presynaptic vesicles of neurons,neuroectodermal and neuroendocrine cells, its function is synaptic transmission , Its presence is detected by immunohistochemical stains which is used as a marker for these cells.
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Old 03-27-2012
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Default Just one more thing ..

Quote:
Originally Posted by tiger73jo View Post
I agree with most of what u said except 2 things
APUD is Amine Precursor Uptake and Decarboxylation tumors.
Synaptophysin is a transmembrane glycoprotein found in the presynaptic vesicles of neurons,neuroectodermal and neuroendocrine cells, its function is synaptic transmission , Its presence is detected by immunohistochemical stains which is used as a marker for these cells.

Here is more info:
SYP synaptophysin

This gene encodes an integral membrane protein of small synaptic vesicles in brain and endocrine cells. The protein also binds cholesterol and is thought to direct targeting of vesicle-associated membrane protein 2 (synaptobrevin) to intracellular compartments. Mutations in this gene are associated with X-linked mental retardation (XLMR).
Location : Xp11.23-p11.22[provided by RefSeq, Aug 2011]

The protein (Synaptophysin) is present in Neuroendocrine cells and in virtually all neurons in the brain and spinal cord that participate in synaptic transmission. It's a marker for neuroendocrine tumors.
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