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  #1  
Old 01-03-2012
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Drug Antibiotic for Penicillinase producing Staph aureus

An 86-year-old man complains of cough and blood in his sputum for the past 2 days. On admission, his temperature is 103°F. Physical examination reveals rales in his right lung, and x-ray examination shows increased density in the right middle lobe. A sputum smear shows many gram-positive cocci, confirmed by sputum culture as penicillinase-producing Staphylococcus aureus. Which of the following antibiotics would be best to administer?

A. Ampicillin
B. Carbenicillin
C. Mezlocillin
D. Oxacillin
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Oxacillin?
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Old 01-03-2012
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Oxacillin
amox is nt penicillinase resistant
carbenicillin is extended spectrum

no idea of mezlocillin
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Old 01-03-2012
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Oxacillin- its an pencillinase resistant antibiotic along with nafcillin n methicillin.

mezlocillin comes under extended spectrum group specifically ureidopencillins along with pipericillin.
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Old 01-03-2012
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D. oxacillin
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Old 01-04-2012
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d. oxacillin
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Old 01-04-2012
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Quote:
Originally Posted by scopusmount View Post
An 86-year-old man complains of cough and blood in his sputum for the past 2 days. On admission, his temperature is 103°F. Physical examination reveals rales in his right lung, and x-ray examination shows increased density in the right middle lobe. A sputum smear shows many gram-positive cocci, confirmed by sputum culture as penicillinase-producing Staphylococcus aureus. Which of the following antibiotics would be best to administer?

A. Ampicillin
B. Carbenicillin
C. Mezlocillin
D. Oxacillin
Penicillinase-resistant penicillins are cloxacillin, oxacillin and nafcillin. So the answer is D.
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Old 01-05-2012
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yup it is oxacillin
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Old 01-06-2012
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D- Oxacillin. -> antistaph pen.
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Old 01-06-2012
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D- Oxacillin. -> antistaph pen.

B & C fall under antipseudomonas pen.
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Old 01-06-2012
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Quote:
Originally Posted by 1TA2B View Post
Penicillinase-resistant penicillins are cloxacillin, oxacillin and nafcillin. So the answer is D.
Cloxacillin, Oxacillin, Methicillin, Nafcillin, Dicloxacillin .. “COMN Denominator” is my little mnemonic




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Old 01-06-2012
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What would have been the mode of resistance had these drugs developed resistance to Staph aureus?
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Old 01-06-2012
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Quote:
Originally Posted by indigo View Post
What would have been the mode of resistance had these drugs developed resistance to Staph aureus?
You mean Staph developed resistance to these drugs? Changing the Penicillin binding proteins ..
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Quote:
Originally Posted by Dr_Swagg View Post
You mean Staph developed resistance to these drugs? Changing the Penicillin binding proteins ..
True.....resistance to these drugs would be acquired via change in pencillin binding proteins....change in PBP's- always remember MRSA!!!!!!
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Old 01-06-2012
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D. Oxacillin
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